CompPharm - Benfotiamine - Neuroprotective | Alcohol and Nicotine dependency | Anti-Cancer Properties

Thiamin (thiamine), or vitamin B1, is a water-soluble vitamin found naturally in some foods, added to foods, and sold as a supplement. Thiamin plays a vital role in the growth and function of various cells.

Benfotiamine is a lipid-soluble derivative of thiamine. The increased lipid solubility of benfotiamine allows it to penetrate nerve cells more easily. After oral intake, benfotiamine shows increased bioavailability compared with an equivalent dose of water-soluble thiamine. Benfotiamine may, therefore, be a better option to treat thiamine deficiency than its water-soluble counterpart.

How can Benfotiamine help?

- Prevent diabetic neuropathy 

- Cognitive improvement in Alzheimer's disease

- Overcoming alcohol dependence

- Assist in quiting smoking

- Kidney protection

- Antitumor potential 

- Antioxidant properties

Each container contains:

120 x 150mg capsules

Serving size: 2 Capsules

Servings per container: 60 (2 month supply)

Benfotiamine mechanism of action:

Benfotiamine acts by modulating the advanced glycation end products (AGEs). It can also act through non-AGE dependent pathways.

Advanced glycation end products are modified proteins or lipids that become non-enzymatically glycated on exposure to sugars such as aldose. AGEs may generate reactive oxygen species, attach to specific receptors, and form cross-linking structures.

AGEs are present in the diabetic vasculature and involved in the progression of atherosclerosis. Benfotiamine inhibits the synthesis of AGEs and thus decrease the metabolic stress. Benfotiamine thus helps in vascular complications associated with diabetes.

Benfotiamine can also regulate non-AGE dependent pathways such as nuclear transcription Factor κB, vascular endothelial growth factor receptor 2, and glycogen synthase kinase-3β (GSK-3β). It can also modulate mechanisms related to cell survival, repair, and apoptosis.